What you notice
Your pump primes quickly and runs strong in recirculation, but in filter mode it struggles to catch prime, takes longer than it used to, or loses prime intermittently. Once it's running, the returns feel weaker than they should.
What it usually indicates
This is the single most useful diagnostic most pool owners never think to run, and it's free. In recirculation, water bypasses the filter media and routes straight back to the returns. In filter mode, water has to travel through the entire media bed and the lateral assembly before it gets there. If everything upstream of the multiport is healthy in recirculation, the difference between the two modes is essentially the filter itself.
When prime won't hold in filter mode but holds fine in recirculation, the resistance is somewhere between the multiport and the returns — fouled or compacted media, a broken or partially-blocked lateral assembly, internal damage, or a valve setting that's restricting one path more than the other. When prime won't hold in either mode, the issue is upstream of the filter — suction-side leaks, clogged baskets, low water level, or a worn pump lid o-ring.
I ran this test on my own pool by accident, two seasons in a row, before I realized what it was telling me. The system would prime up cleanly in recirculation and then fight me the moment I switched to filter. That asymmetry is the smoking gun for a filter-side problem, and it ruled out a half-dozen suction-side rabbit holes I'd otherwise have chased.
What to verify first
Run the system on recirculation for a few minutes and watch how it primes and holds. Then switch to filter and watch the same metrics. If the difference is dramatic, the problem is downstream of the multiport — open the tank.